Coclé artwork is representative of Panamanian polychromatic styles, in which pigments are baked onto artifacts to give them a variety of colors such as white, black, brown, dark red, light red, and purple, sometimes all of them in a single piece. They painted zoomorphic and stylized designs onto their ceramic pieces, and their vessels included small bowls, elongated beakers, carafes, and plates with ring-shaped or pedestal bases. Some Coclé vessels are decorated with images of tortoises, birds, and snakes—sometimes snakes with feathers—while others include effigies with faces, humped backs, and masks. Other items found often include ceramic rattles. Another feature of Coclé decorative style is the use of black on white pigment, with motifs in the form of the letters Y, V, or T near the edges of vessels. In ceremonial pieces, these shapes are applied in red. Another unique design in this ceramic tradition is the so-called Ala de Coclé, the Coclé Wing. At the site of El Caño, several columnar stone statues covered with zoomorphic designs have been found, as well as some with anthropomorphic designs in relief. The site has been interpreted as a temple, as it also features a central altar that is also decorated with zoomorphic forms.
Other stone artifacts often ascribed to the Coclé culture include maize grinding stones carved with zoomorphic figures, generally feline and sometimes very large. These stones stand on four legs, and their finely worked craftsmanship suggests that they were not for domestic use. Some have been found with highly polished cylindrical grinding stones. Other grinders ascribed to the Coclé have zoomorphic motifs on their handles, made of semi-precious stones. These may have been used for grinding pigments or some other substance used in rituals. The Coclé people also made earrings from agate and serpentine, and they used rough quartz to make beads that were set in gold artifacts. Gold pieces associated with this culture show local styles and motifs related to regional chieftains.